Foundation Medicine presenting next week…

There seems to be some overlap between Foundation’s genetic testing and the immunotherapy treatments coming down the pike (the area Nektar-214 and 262 seem to be in).

From the release:
In the area of immunotherapy, new data will be presented highlighting the use of Foundation Medicine’s bTMB assay, which is currently being utilized in a global clinical trial setting to investigate bTMB as a non-invasive biomarker of response to first-line atezolizumab in advanced non-small cell lung cancer (NSCLC) patients as part of Roche/Genentech’s prospective, randomized Phase III Blood First Assay Screening Trial (BFAST). Previously this assay was shown to be associated with response to the anti-PD-L1 immunotherapy agent, atezolizumab, in individuals with previously-treated NSCLC. New data to be presented at AACR builds on these findings, showing that: (a) high TMB is significantly associated with improved survival on atezolizumab versus chemotherapy in second-line NSCLC, (b) measurement of high TMB using Foundation Medicine’s assays in blood versus tissue is correlated with, and is largely explained by, shared variants present in both sample types, and (c) a sufficiently-sized assay is required to reliably characterize patients with high TMB.

Additional findings to be presented may help further guide the use of checkpoint inhibitor cancer immunotherapy. For example, one study found that tumor mutational burden (TMB), which has been shown to predict response to immunotherapy in many cancer types, varied between patients of different ancestries, suggesting that the likelihood of benefit from immunotherapy may differ in these patients as well.