Health, the microbiome and diet

The gut microbiome (the vast and variable assembly of microorganisms that live in our gut that represent 90% of the cells in our body) has a huge impact on our health. The friendlies fight off pathogens. They digest food that humans don’t have enzymes to break down, produce beneficial chemicals and vitamins and even produce serotonin that affects our moods.

Everyone has a unique microbiome which is affected by many factors. The microbiome has long been known to have a strong impact on health.

A recent study shows that the microbiome reacts quickly to diet. “Survival of the fittest” rules the gut. Some microbes thrive on a healthy diet but can’t deal with junk food. Other microbes thrive on junk food and out-compete the others on a junk food diet.

A recent, very thorough study shows that health and BMI are closely associated with specific microbes in the microbiome. The health problems associated with the junk food loving bugs are the well-known chronic ills associated with the Standard American Diet – obesity, diabetes, cardiovascular disease and cancer.

Cause and effect still aren’t clear. Do the friendly microbes that thrive on the Mediterranean diet contribute to maintaining health? (and the reverse). Or are both the microbiome and health independently associated with a diet of vegetables, fruits, legumes, whole grains, etc.?

One interesting result of the study is that a change in diet rapidly results in a change of microbiome balance. (Within 90 days.)

Because health has such a huge Macroeconomic impact, this is clearly on-topic. Not to mention that the processed-food giants would evaporate tomorrow if everyone followed the healthier path since they produce nothing (except bottled water) that the friendlies can eat. Bye-bye, Coca-Cola, Pepsi, Frito-Lay, McDonald’s, etc.

https://www.nature.com/articles/s41586-025-09854-7?utm_source=substack&utm_medium=email&lid=qeo8lfinldvo

Wendy

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Your post covers the topic so well that I will limit my response to that part of your post referring to the production of serotonin that affects mood. In my never ending battle to improve my sleeping patterns I stumbled upon a fair number of studies purportedly showing that a combination of prebiotic high fiber foods (oats, beans, etc.), and probiotics (yogurt, sauerkraut, kimchi), facilitated the production of serotonin and melatonin. Follow-up studies have shown improvement in quality and quantity of sleep in people who adhered to high prebiotic/probiotic foods daily for a period of 8 weeks or more.

It is too early to report back on my personal study using me as an N of one, but my after dinner dessert the last few weeks have been a small bowl of oats, natural peanut butter (nuts and salt only), and plain Greek yogurt. If my sleep improves measurably, I may come back and brag about it. Fingers crossed.

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An even more limited response @iampops5 …… but on the Greek yogurt, I can recommend this for high levels of the other P. Protein.

I’ve discovered that not all Greek yogurts are created equal where protein content is concerned, and that a couple of brands are in the single digits per serving!!

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