Old TB vaccine primes immune system, amazing results

BCG, a live vaccine for tuberculosis developed in 1900, has been shown to significantly reduce mortality from other diseases. Including other infectious diseases and immune-related diseases like Type 1 diabetes, cancer and Alzheimer’s disease. The effect is thought to be related to epigenetic changes on the level of DNA affecting the innate immune system.

The results are amazing. But the vaccine has been off-patent for decades so no pharmaceutical companies are interested in investigating it. A dose costs 6 cents. BCG given at birth to children from Guinea-Bissau with low birth weight reduced all-cause mortality in these children by about 40 percent in the first year of life. The reduction in mortality was the result of fewer cases of non-TB infections, which the vaccine protected against in an undetermined way.

Researchers are trying to develop fancy-schmantzy alternatives that can be patented (such as parts of the TB bacillus attached to nanoparticles). Obviously, these would be far more expensive even if they aren’t more effective than the old BCG vaccine.

Studies show that BCG vaccination can help older people with weakened immune systems. It doesn’t have an effect in healthy adults.




Thanks excellent find. Probably going to be big news.

The Defense Production Act should be called upon. This should be mandated production. The savings to the nation is massive. This cost wise otherwise is as large as a pandemic or more and ongoing.

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Be interesting to see if Mark Cuban’s facility is interested in producing it.


I truly admire Mark Cuban. But this is a chicken-and-egg situation. The treatment is still controversial. Until it is approved for widespread use it wouldn’t be added to a drug list.