Joe Edelman at Perceptive Advisors has turned a $6 million dollar hedge fund into a $4.1 billion hedge fund. 30% annual returns since 1999. 130-bagger.
And he invests almost entirely in biotech.
You can read about him here and here:
https://www.institutionalinvestor.com/article/b19hj4gjrwh1x9…
https://www.forbes.com/sites/nathanvardi/2018/04/10/a-sixth-…
If you want to go shopping, you can find his holdings here:
https://www.nasdaq.com/quotes/institutional-portfolio/percep…