The food industry has developed far faster than biology can cope with and has generated the obesity epidemic. Medicine to the rescue. The linked video is an interesting examination of the Biological Cost.
The Captain
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I’m unlikely to watch a 30 minute video from someone who may or may not be a crackpot. For politeness sake I’ll assume he is not, but that doesn’t make his assessment right or worth the time, either.
For instance: we treat all sorts of things with “biological consequences”. Vaccines have saved millions, probably billions of lives by artificially altering our immune systems in favor of early detection of diseases, plagues of which have ravished humankind since the beginning of time.
I personally have used steroids to overcome breathing trauma. Should I not do so, when the result could be my death? We use all sorts of pharmacological products with clear designs to achieve certain artificial results - with clear designs to improve life.
Which does not mean there can’t be negative effects as well. One with some of the weight loss medications is a loss of muscle mass along with the fat component, and that might not be advisable for many people. But then the “artificial” loss of 50 or 100 pounds might be extremely advisable for those who are morbidly obese, contraeffects be damned.
What is his point?
(Like people who hate naked links without any explanation of what the user is likely to find at the other end, I feel the same about naked linked videos, a short summation of the content would be appreciated.)
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Here ya go:
{ ďż˝
The speaker is a pathologist explaining the biological impacts of popular GLP-1 drugs Ozempic and Mounjaro. ďż˝
These drugs originate as diabetes medications but are now widely used off-label for weight loss. ďż˝
They work by mimicking gut hormones to suppress appetite and slow digestion. ďż˝
Rapid weight loss can lead to metabolic and physiological side effects beyond intended benefits. ďż˝
The video highlights changes in organ and tissue responses due to prolonged drug use. ďż˝
Some side effects include nausea, gallbladder issues, and digestive complaints. ďż˝
There’s discussion about muscle mass loss and nutritional deficiencies with extreme weight loss. �
The pathologist emphasizes the need for medical supervision when using GLP-1 drugs. ďż˝
He also addresses long-term unknowns and potential immune or hormonal impacts. ďż˝
Overall message: understand risks and biological costs before choosing these medications. ďż˝. }
As frankenfurter says: this short description of the video
“will remove the cause, but .. not… The symptom!”
ralph
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I nominate as the most delectably delivered dark line in American Musical history. That was the moment (at about 1 AM in a packed theater of lunatics) that I was hooked too.
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This was the one that got Mrs. Goofy. She was not crash dieting, mind you, taking the minimum dose, and although it worked for weight loss, it also led to pretty severe tiredness and muscle loss.
She went from hiking 5 miles in a day to being overtired after a mile, mile and a half. And once she read that it could cause muscle weakness, loss of mass, etc. she went off it, and within a month or two was back to her full vigor and regimen.
I was on it too, and yes, it made me a bit weaker, but not enough to make me quit. (I did quit when the supplier changed to a different compounder, which gave me an unpleasant reaction). Then again, I’ve been sedentary for most of my life. Exercise and I don’t really like each other very much.
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These are good to know!
For 5 years I’ve had trouble walking more than a couple miles.
Gout in my feet n ankles.
No walking, I’ve gained weight.
After 18 months of allopurinol, my foot pain has changed. I’m now walking 5 miles again. And a bit more.
I’m set up to consult on GPT-1, and am considering “no”.
Cause “meds have side effects”, n I’d rather avoid that until absolutely, obviously no other choice
ralph
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One needs to look at the whole picture. Unfortunately medicine is often about symptoms and not about causes. If you need to lose weight it means that somewhere along the line you gained weight. Why? How? Weight medication does not care but one should. If you discover the reason for being overweight you might find a way of deal with it more naturally than with medication.
I was 20 plus pounds overweight and had a whole lot of health problems but too busy to find out why. Hints of steak and salad did not work. Later in life I started to read about the issues and finally discovered the causes. Tasty, cheap, highly processed garbage food loaded with sugars and highly processed seed oils. Simply by eliminating garbage food the excess weight simply evaporated over time, I don’t remember how long it took but at least a year.
Once you stop poisoning your body it works just fine to fix itself. Down from 90 to 70 pounds was all I needed to jettison all the medications that had been prescribed for life for all my “incurable” ailments that cured themselves once the poisons were stopped.
Eating less is difficult. Eating different is easy once you know what to avoid and you can ignore calories, the body, once rid of the poisons, regulates hunger quite well as it that been trained by evolution for millennia.
The Captain
Factoid: To make foods low fat requires a lot of processing. Good fat is good, no reason to cut it out. Cut the highly processed seed oils, vegetable butter (margarine), and artificial shortenings (Crisco). Now I cook with lard and season with olive oil.
Factoid: One of the worst diet recommendation was to graze all day like cows do. Intermittent fasting is healthy. Eat one or twice a day. No in between snacks.
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AND, more or less, it is also normal to our species to have a weekly or so day of low diet or even fasting, and a day of celebration feasting. Almost all religious orders do this, and most of our ancestors did also — as part of normal hunter gatherer life.
I learned from growing up in my family’s culture, greatly enhanced by weeks of mountaineering, that my body loved mostly intense fat burning days mixed with recovery days mixed with some feasting here and there. Heaven on Earth.
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Well, yes…..creating and maintaining a sufficient energy deficit to produce an adequate weight/fat loss by managing your dietary habits is preferable to spending money on medication to help you do the same. I would’ve assumed you’d given that a go already?
If your own reasonable efforts aren’t working, I wouldn’t be too quick to nix the idea of using a GLP-1 receptor agonist based on a focus on side effects that might not in and of themselves be due to the medication…but rather the rapid, large weight loss associated. Reason these side effects are attributed so frequently to these meds by the general public is that it’s a phenom (rapid, large, sustained weight loss) hasn’t really been seen on this scale before, right?
I’ve written about my daughter’s experience elsewhere. She has steadily lost about 30 lbs over 7 or 8 months. Has weaned off the lowest dose successfully (all she ever used) and experienced no adverse side effects beyond a bit of excessive “corkage” in the early days. By virtue of very close attention to diet, especially protein, and well planned exercise programme…..established months before even contemplating Ozempic in her attempts to lose weight “naturally”….she’s successfully maintained (actually built) muscle and dropped visceral as well as subcutaneous fat.
Granted, she probably wasn’t a genuine fat person in the first place as her weight gain was somewhat situational and over a shortish period. If your extra lard is the outcome from a drop in energy expenditure from your Bad Feet (and I’m also a member of that club!), your experience might well mirror my daughter’s.
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P.S….it’s worth pointing out that, yes, the speaker on this video is a pathologist, but his field seems to be dermatology (when accosted by these YouTube videos, I usually check out the background of the speaker before I contemplate watching….I did that when you first posted this a few daysago, Ralph) Doesn’t mean that he’s necessarily ill qualified to pass an opinion….just serves to explain the lack of nuance in his delivery. Now, an endocrinologist specializing in this field…..or even a transplant hepatologist with a strong background in GI and a research background in these gut hormones (like my husband….who’s still smarting over secretin!!) might give a more measured explanation that’d allow for worthwhile decision making.
..
I lost 50 pounds with Noom before the drugs. I am not going on the drug. But decades ago I was in Overeaters Anonymous. Don’t know if I will join the program again. I am using those principles against GLP-1. It is working. There is more outside of us aiding us than within our hormones.
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