OT: Cancer ‘vaccine’ eliminates tumo

I know we have a lot of CAR T-cell therapy experts on the board so I wanted to post a link to a therapy I hadn’t come across yet until today. Seems interesting.

From here:

Activating T cells in tumors eliminated even distant metastases in mice, Stanford researchers found. Lymphoma patients are being recruited to test the technique in a clinical trial.

Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine.

The approach works for many different types of cancers, including those that arise spontaneously, the study found.

The researchers believe the local application of very small amounts of the agents could serve as a rapid and relatively inexpensive cancer therapy that is unlikely to cause the adverse side effects often seen with bodywide immune stimulation.



I saw this article this morning too. Immune therapies are opening up an incredible new era. Of course, mice are a long way from people. On the other hand, this is not like screening 1,000 small molecule drugs to find one. This is more focused research (so far as I can tell- I am a chemical engineer, not an MD or biochemist) so the number of approaches is more limited and the chances of success should be higher.

Extremely exciting stuff!