Not really OT in terms of the macroeconomic cost of late stage responses to metabolic dysfunction.
An interesting random (not so random?) page on my FB feed this morning addressed the timescale of the early departure from healthy metabolic homeostasis with insulin resistance being the canary in the coal mine. The article included one study with a neat graph showing this trajectory from normal fasting glucose, through to undeniable full blown disease. Tracked down the study…
Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study - PubMed Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study - PubMed
Interesting to note the date of publication. I couldn’t find the thread on reclassification of the distinction between prediabetes and full blown T2D so a new thread it is.