I am guessing you want to access it from multiple devices???
If so, I have no experience, but if you can mount the cloud storage in a directory, then I would think you can point Calibre at that directory. Easy enough to try.
My own solution is to use Calibre Companion to create a walk around copy.
Yes, keeping oneās entire library on a tiny USB stick or external SSD is the ultimate security I suppose. Even I I donāt yet trust cloud storage to be truly āpermanentā.
And this how-to on making Calibre use a library in cloud storage seems straightforward:
Iād like a master copy that can be accessed from anywhere and not have to worry about keeping a local copy. Itās just simpler that way. And it would probably be more secure and safer than keeping a local copy on a portable disk. Iād want at least two local copies for redundancy. But of course, the library could be kept both in the cloud and locally.
I have four devices that Iād want to be able to read from: Windows laptop, Apple iPad, Kindle Paperwhite, and Android smart phone. Cloud storage would probably be the most consistent and easiest way for all of them to be able to access a library.
Not 100% sure about the iPad, but the phone is exactly what Calibre Companion is made for. You bring the device near the computer, establish a wireless connection, it updates changes to previously downloaded data, you download any new books, disconnect and go your way. I would guess the same is true for the iPad. Not sure I know what you would do with the Kindle except to push updates to it with the match feature I referred to earlier.