Seems to be pretty common timing. Women for the most part seem to be protected pre-menopause.
https://www.sciencedirect.com/science/article/abs/pii/S1933287422003269?dgcid=author
The independent associations of anti-Müllerian hormone and estradiol levels over the menopause transition with lipids/lipoproteins: The Study of Women’s health Across the Nation
Article regarding this study, which is in English vs overly technical: https://www.sph.pitt.edu/news/hormone-may-be-missing-ingredient-heart-healthy-cholesterol-levels-menopausal-women
Dr. El Khoudary’s team analyzed blood samples from the Study of Women’s Health Across the Nation (SWAN), which followed a diverse group of 1,440 midlife women through the menopause transition. These blood samples were tested for estrogen and AMH levels as well as good and bad cholesterol.
Through this study, Dr. El Khoudary found that, while high estrogen level was important for lowering LDL-C or bad cholesterol levels, high AMH was responsible for lowering HDL-C or good cholesterol. This means that as women traverse the menopause transition, they lose estrogen and AMH, increasing both their bad and good cholesterol levels.
This may sound contradictory but, to Dr. El Khoudary, it supports her suspicions that good cholesterol is not always good for menopausal women. Previous studies from Dr. El Khoudary’s group have determined that good cholesterol levels in these women could be masking other cardiovascular issues and may even be a sign of HDL dysfunction, preventing good cholesterol from performing its cardioprotective duties.
FWIW,
IP