Ozempic, and other GLP-1 drugs

It has been recognized in principle, but I don’t think many people have internalized the possibility that this could be a miracle cure for alcoholism. At least as long as you take it.

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It’s interesting how much sanctimony there is about off label usage of this drug. I’m currently doing an online training course designed to address the specific needs of strength and fitness training for women. Designed for personal trainers/group ex. instructors etc…and with an accompanying closed FB page where we can bounce ideas off each other.

I actually posted a question yesterday asking if anyone had experience of training any clients (male or female) who were using GLP-1 agonists for weight loss without the usual biomarkers for metabolic syndrome T2D etc. and at lower BMI than officially obese. Specifically if anyone was having difficulty gaining or losing muscle mass to a greater degree than one would expect. This is a big group in all manner of far flung places so I imagined maybe 1 or 2 might have insight. One gal…an MA at a medical facility had seen 4 patients/clients but they were obese/morbidly obese and no one else (as yet)

But ooooh the opinions…especially of the nature of “I don’t believe in quick fixes and wouldn’t work with anyone using this drug for non medical reasons” (as if they actually understood the medical implications of excess bodyfat and early departure from healthy homeostasis) I refrained from asking “and how’s that business model working for ya?!?” because I’m hoping some brave soul will admit to stooping so low as I see a useful potential for heading metabolic dysfunction off at the pass. Can’t imagine why a lifetime of a low maintenance dose of one of these drugs (assuming safety issues are not a problem) is deemed worse than any of the Usual Suspects that are prescribed when metabolic syndrome gets a foothold.


This! I agree VN.

I can visualize some folks being successful when taking it for a period of time, then off for a period of time, then “on it”… Repeat.
Similar to the official/package instructions for use of Nexium or Prilosec.

We’ll know how it affects people In the fullness of time.

There a WSJ article about this phenomenon today -

The ‘King Kong’ of Weight-Loss Drugs Is Coming

Eli Lilly’s Mounjaro could outpace Ozempic as the most powerful treatment on the market. To develop it, the drug company needed to overhaul long-held but failing practices.


Better yet, an adjunct to assist in refocusing the lenses. Like, for instance, folk still fall for the tomfoolery that accompanies energy balance denialism…if nothing else, it provides a practical example that, yes, if you eat less you do lose weight.

Now, I can’t see how it’d help folk reach the “Aha!” moment or to find their “why” any more than happens with Righteous Eating … or be any more successful with long term weight management, for that matter. It’s surely a darn sight better to make an attempt early…even for (shock, horror!!) plain old vanity’s sake … than waiting until the train’s so far along the track to outright disease, there’s little chance of reversal.


Can you tell me more specifics about this? I’m interested to know the details of your diet.


Sorry if I’m off topic here. I’m not sure if there is a way to email the author directly any longer so posting this here.

Sure AJ,

There is the theory that the belly being full is based on weight. Water is weight.

There is the theory that raw foods need more energy to unlock their energy than cooked foods.

I’d say between 20 and 40% of my diet each day falls into these foods.

But, more specifically, you’re actually eating less, right? You’re paying for a Noom subscription (or following those ideas from when you did) and this is just one addition to all those other things that helped along the way.

Useful as it’s been for you, it’s a bit disingenuous to imply that this “one simple trick” is all it takes.

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I did not have time earlier for a full answer. I did not mean to be “disingenuous”.

To AJ, I wont answer in full for a good reason never mind the time involved or anything else.

I will explain. When I began to have success one of my sisters a month after I began decided to join me. There are as VeeEnn is saying several factors. I told my sister I would not tell her what the program entails. I wanted the experience to be all her own.

My sister and I supported each other every Saturday for a few months as we lost weight. But I never explained anything to her. She lost 28 lb and I lost 50 lb. Hugely successful.

VeeEnn, I am sure you can show off or cite a lot of other stuff about this response as well but DONT. Don’t ruin it for someone else who needs to find his way without you telling all as if that is a solution. In your medical practice that is directly your job. But in this his individual experience matters more than anyone else’s bull on a message board.

My sister made a mistake. Mom wanted to know about Noom. So Eve told her all about it. Of course that completely ruined it. There is no telling all about it. The moment mom mistakenly thought she knew the program she NEVER joined it or did it. Mom decided she had it down pat. Mom has no clue what Noom is to this day and insists she did the program. Through entirely other means mom lost 14 lb but has not kept all of it off longer term.

The point is let people have their own experience.

AJ I recommend Noom. You go figure it out if you want to on your own. You will be much happier and much more productive than getting information on an internet message board. You do not need us at all.

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It seems most of it boils down to people with $$$ getting the drug to loose 10 pounds while a diabetic that really needs it might be struggling to find it. And basic economics of supply and demand, $$ that not everyone can afford.


Well, me, I’d file that under “legitimate concern” or perhaps “ethics and morality” rather than sanctimony, surely.

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The celeb crowd are apparently all on the compounded stuff, not on the scarce bramded product.