Ozempic may treat addiction

If Ozempic and Wegovy (GLP-1 receptor agonists) can treat cravings of all types the market will simply explode.

The Breakthrough Drug to Conquer Addiction: Ozempic?

By Maia Szalavitz, The New York Times, Oct. 18, 2024

Could these medications — collectively known as glucagon-like peptide-1 (GLP-1) receptor agonists — also fight America’s most difficult drug problems?

Striking new data suggests they might. On Thursday, the journal Addiction published a study that examined the medical records of half a million people with opioid use disorder and found that those who were taking GLP-1 drugs, for any reason, had a 40 percent lower overdose risk compared to people not on these drugs. The research also looked at the medical records of over 800,000 people with a history of alcohol use disorder, and found that the number of medical visits that noted current alcohol intoxication was halved in patients who were prescribed GLP-1 drugs, compared with patients who did not take the drugs.

In September, another large study of medical records of people with both opioid use disorder and Type 2 diabetes reported that the risk of hospitalization for overdose was cut by 40 to 70 percent if patients took semaglutide (sold as Ozempic or Wegovy) rather than older diabetes medications, including other, less effective GLP-1 drugs…

Significant evidence suggests that GLP-1 drugs may work by lowering the signals in the brain that create craving, with far less impact on the circuits that allow you to enjoy life… [end quote]

Ozempic and Wegovy are manufactured by Novo Nordisk, a Danish company. The drugs are synthetic polypeptides which means they must be injected since they would be digested in the stomach. The drug is so expensive and in so much demand that counterfeiters have sold dangerous fake knock-offs which may contain insulin.

Novo Nordisk is already the largest company in Denmark. If indications pan out the worldwide demand would be mind-boggling.

Wendy

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This has been known about for over a year now the ability to cool addictions.

The side effect profile is still being built and it is not good.

As compared to what? I’d say looking at what’s known about the side effects of uncontrolled opioid abuse or hefting around excessive quantities body fat over the long term, the side effect profile doesn’t seem too bad at all. Certainly not to the extent that I’d perceive investment in Novo Nordisk as something to be wary of.

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That is a difficult problem. Losing the weight through calorie reduction has the benefits without the side effects. People rarely do that.

The hype parade around products like Ozempic is amazing. We are constantly being told the stuff is a cure-all. Isn’t anyone just a teeny bit skeptical?

Steve

Steve

Painful choices

Some folks hunker down