This 24 minute video is the best one about I’ve seen about solving the obesity epidemic.
The core of the argument is that in good health the body creates a sufficient amount of GLP-1 for the body to function as designed. The main GLP-1 killer is highly processed food.
Losing weight is not what cures, weight loss is a side effect of good health. The doctor says that a scale is not the best tool to monitor your health because weight swings a lot. I can attest to that, my average weight is around 70.5 kilos but it swing above 71 and below 70 all the time. Four or five pound swings. A much better and cheaper tool is my leather belt that has recorded by girth for the past 30 years or so years.
Unfortunately, though, this explanation is a bit misleading (says she, euphamistically)…possibly the prompts you typed into the Google Bamboozle search box led you astray. Again.
Although it’s accurate to say that there are potentially adequate amounts of these incretin-like gut hormones produced naturally for weight management, the body doesn’t “stop listening”…it’s because the half life is so short that there’s not enough sloshing around at any one time to maintain an audible signal.
See, the naturally produced hormone is very susceptible to rapid degradation by naturally produced peptidases and effectively disappears (a problem that dh’s lab mates found when studying this hormone back in the early 1980s) The versions known as glp1 receptor agonists have been “engineered” to have enough resistance to overcome this problem.
I bet that, if anyone here succumbed to the temptation to type “why does naturally produced glp1 stop working” into Google’s search box, a whole slew of articles would pop up leading to a whole morning or more’s dive down an associated rabbit hole and give a better informed explanation than this bloke’s.
Endocrinology is the sub specialty to listen to (and I bet there are enough misinformers around under that title)…or better yet someone with a bit of a background in research in this area.
