’ Patients with type 2 diabetes, overweight, or obesity taking the glucagon-like peptide receptor agonist (GLP-1 RA) semaglutide appear to have an increased risk for NAION, an uncommon condition that can cause vision loss.’
In a retrospective study published in JAMA Ophthalmology covering
16,827 patients at Massachusetts Eye and Ear in Boston, researchers ‘assessed the cumulative incidence of nonarteritic [anterior ischemic optic neuropathy] (NAION) during 36 months of follow-up.’
“Given the numbers of participants who have been recruited to clinical trials and the large number of people globally who use GLP-1 RAs, we should be confident that if corroborated, the absolute risk of developing NAION in direct relation to taking semaglutide must indeed be rare,” Susan P. Mollan, MBcHP, of University Hospitals Birmingham NHS Foundation Trust, in England, wrote in a commentary published with the study.’
“Given the numbers of participants who have been recruited to clinical trials and the large number of people globally who use GLP-1 RAs, we should be confident that if corroborated, the absolute risk of developing NAION in direct relation to taking semaglutide must indeed be rare,”
Episode of The Simpsons. Homer is testing a new appetite suppressant drug. It makes him go blind. One scientist says to the other: “Who would want to take a pill that makes you go blind?” The other scientist says something like: “That’s marketing’s problem.” They give each other a High Five.
Yes, nothing matches the Simpsons in acerbic humor, deadly futuristic imagineering, and political economical spiritual prophecy.
In three centuries students (if there are any) will be arguing how Western Civilization destroyed itself when it had such a clear self-diagnosis ready to hand…
I was discussing these drugs with my wife earlier today while we were driving. I wonder if in 20 or 30 years from now, there won’t be a wide study (normalized for everything) showing that the population of folks on these drugs have 27% fewer children than folks not on these drugs. Or some other population-level side effect that can’t be measured individually or in small groups (like a sample of 3000 may be valid for most individual side-effects, but for societal side-effects you need hundreds of thousands or millions and a lot of time).
