Long Covid and autoantibodies

This research looks at predicting a person’s potential for “long covid”.

Presence of autoantibodies most predictive of long COVID in study (Jan 26, 2022)
https://www.mdedge.com/internalmedicine/article/251199/covid…

A deep molecular dive into COVID-19 patients found that the presence of autoantibodies in peripheral blood at initial diagnosis was the chief of four risk factors predicting if a patient would experience long COVID.

Snip

Study Findings
With COVID patients monitored for 2 or 3 months, the study findings of the international “multiomic profiling” analysis include:

Subclinical patient autoantibodies that reduce anti–SARS-CoV-2 antibodies suggest there is immune dysregulation during COVID-19 infection.

Reactivation of latent other viruses during initial infection may be contributing to long COVID.

Gastrointestinal postacute sequelae of COVID presents with a unique postacute expansion of cytotoxic T cells.

SARS-CoV-2–specific and cytomegalovirus-specific CD8+ T cells displayed unique dynamics during recovery from infection.

According to the authors, as many as 69% of COVID-19 patients suffer from long COVID – a range of new, recurrent, or ongoing problems 4 or more weeks following initial SARS-CoV-2 infection. These may include memory loss, gastrointestinal distress, fatigue, anosmia, and shortness of breath.

Autoantibodies- auto = self, so antibodies that target NORMAL, SELF cells and tissues.

Autoimmune is a similar term, ie a disorder in which the immune system (antibodies and Tcells) mistakenly target normal, self cells and tissues. There are 20+ “autoimmune disorders” that are associated with various viruses or other pathogens.
These autoimmune disorders are “long virus/pathogen”.

Arthritis, Graves Disease, MD, etc.

Long Covid is not a new phenomenon, it is merely the first time the popular media has reported the phenomenon, and caught the attention of the masses.

The covid pandemic has had many “bad” effects, but it’s also shown some silver linings?

Perhaps the above described research will lead to better understanding and treatments for autoimmune disorders?

The bolded reference to reactivation of latent viruses catches my interest.
Many folks suffer from labial and genital herpes, a virus that is latent, until some factor (Stress from emotional or physical causes) reactivates it.
Guillaume Barre is perhaps one such “latent” virus that is activated by COVID-19?

Shingles is activated during cancer treament by “immuno suppressent” chemo?

:alien:
ralph

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