Well, you can usually rely on press releases to over hype whatever the press release is about…whether it’s a news item about side effects, the positive results of a study or the benefits of a brand new drug. I don’t bother with them beyond pointing out the misleading nature of them (which, I guess applies to this one you can’t find)
As for your figures on phase1 to 5 years post introduction to market, I have no reason to disbelieve that…but, taken at face value, it’s again misleading. Of the 94% that gets withdrawn, I’d guesstimate close to 94% of that figure represents the number that don’t even make it beyond phase 1…with more falling by the wayside even before they receive FDA approval. One reason that novel drugs are expensive to produce.
And, of course, increased dosage has a greater potential for producing side effects…that’s the case with any medication new.or old. Ozempic, metformin…aspirin, tylenol. A sensible person would be advised not to do that.