Weight loss drugs for liver and kidney disease

Wegovy and Ozempic are drugs manufactured by the Danish company, Novo Nordisk, to treat diabetes. Within the past year or so they have been approved as weight loss drugs. The sales skyrocketed to the point that the GDP of Denmark soared. Novo Nordisk’s sales accounted for approximately 9.9% of Denmark’s GDP in 2024.

That’s pretty unbelievable. But the best news for any pharmaceutical company is that their drug has been approved for another common chronic disease. They already have the sunk cost of drug development and manufacturing. All they need to do is run a clinical trial on a new disease.

https://www.nytimes.com/2025/08/18/well/fda-approves-wegovy-mash-liver-disease-fibrosis.html

A Common Weight Loss Drug Can Treat Severe Liver Disease, F.D.A. Says

Wegovy has been approved for use among the growing number of Americans who have MASH.

By Dani Blum, The New York Times, Aug. 18, 2025

The Food and Drug Administration approved the weight loss drug Wegovy to treat an increasingly prevalent liver disease on Friday.

Roughly 15 million people — six percent of adults in the United States — have metabolic dysfunction-associated steatohepatitis, known as MASH. Rates of the disease are rising….

The list of conditions for which scientists are studying these drugs keeps growing. The F.D.A. approved Wegovy last year to reduce the risk of heart attacks and strokes in people who are overweight or obese; in January, the agency cleared Ozempic — which contains the same compound as Wegovy — to treat kidney disease in people with diabetes. Zepbound, a similar obesity medication from competitor Eli Lilly, won approval for people with obesity and sleep apnea in December. [end quote]

My dear, sweet mother-in-law died of MASH, which used to be called “non-alcoholic fatty liver disease.” She never touched a drop of alcohol but ate every meal at the family’s American-style diner which served the Standard American Diet (SAD). She wasn’t obese but had a typical overweight American woman’s soft body since she never worked out.

@captainccs has told us over the years how he reversed his chronic illnesses by improving his diet. But the CDC has told us that obesity in the U.S. is only increasing.

Novo Nordisk stock has collapsed from its 2024 peak since Eli Lilly now has a competing drug. The profiles of these stocks are completely different. But both of them are leading pharma companies and their products’ uses are growing.

Wendy

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Denmark’s GDP is a bit larger than that of Connecticut. Cigna, headquartered in Connecticut, has annual sales that are over 70% of the state’s GDP. That’s the result of international companies.

DB2

The internal fat around the organs seems to be the really bad fat.

You have to improve your diet to lose weight. Over the last year or so I have lost an additional 5 to 10 pounds with intermittent fasting. It happened accidentally. The body only has enough resources to either exercise or digest food, the reason they tell you not to go swimming right after eating. Not having much to do I go on long walks, the exercise prevents getting hungry effectively skipping lunch. Two meals a day is a mild form of intermittent fasting.

The Captain

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It’s true that fat around the organs is bad.

But the fat in MASH (metabolic dysfunction-associated steatohepatitis) is actually inside the liver, not around it. Without treatment, MASH can cause serious and potentially life-threatening complications by scarring the liver and/or causing liver cancer. MASH can be fatal.

MASH can also cause dementia by the buildup of poisons in the blood that poison the brain because the liver fails to remove the poisons. (Hepatic encephalopathy.) This happened to my mother-in-law. Knowing in advance that she had MASH helped us to recognize it when it happened and not be blindsided by her sudden dementia.

Wendy

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Here you go, Wendy….you might be interested in this…

The effect of obeticholic acid on hepatic blood flow in isolated, perfused porcine liver: Correction of oxygen‐nutrient mismatch might be a putative mechanism of action in NASH - Lake‐Bakaar - 2022 - Clinical and Translational Discovery - Wiley Online Library https://share.google/9C5c5SzdnYtwtuGbX

It’s really a series of proof (testing) of concept studies that’s sort of taken over from HepC with dh’s research…

It’s another one of those serendipitous, “Now, that’s peculiar…..I wonder if???” moments.

He’d been working remotely with some people at Virginia Tech back when he was at Harvard to develop a true cardio-mimetic pump. The better to study sick, explant livers.

When we moved here to Colorado and he got tempted back into harness, he noticed…..and happened to mention…. that folk with alcoholic liver disease and NAFLD were developing cirrhosis much earlier/younger age than he’d see before. “Bloody altitude”, sez I (I blameeverything on it!) He got to wondering, lo….a project was born

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