The combination I run:
Firefox
Pi-Hole (internal network DHCP and DNS server, eliminates a huge amount of advertising and trackers, can be extended to also block social networks, fake news sites, gambling, porn, etc)
FB Purity (blocks most of FB’s inane sponsored by and games playing crap, restores ‘newest first’ timeline, other nice things)
uBlock origin (cookie blocker, mostly)
Malwarebytes Browser guard (block background crypto mining and crap like that)