MIT research team combined photo/heat therapy with chemotherapy to treat “hard” tumors.
https://pubs.acs.org/doi/10.1021/acsnano.4c07843
{ In a mouse subcutaneous model of 4T1 triple-negative breast cancer, 25 microparticles were intratumorally administered, and after 3-cycle laser treatment, the system conferred synergistic phototherapeutic and chemotherapeutic effects. Our on-demand, pulsatile synergistic treatment resulted in increased median survival up to 39 days post start of treatment compared to untreated mice, with complete eradication of the tumors at the primary site. }
Shows promise.
ralph